International Journal of Leprosy and other Mycobacterial Diseases

ISSN 0148-916X

Vol. 55(4 Suppl 1) N° 4 - Oct/Nov/Dec - 1987

PREFACE

1- Preface

S. K. Noordeen

DEDICATION

2- Charles C. Shepard 1914-1985

S. K. Noordeen

WORKSHOP FACULTY, PARTICIPANTS AND OBSERVERS

3- Workshop faculty, participants and observers

PROGRAM

4- Program of the first joint workshop on experimental chemotherapy of leprosy

INFECTION OF THE IMMUNOLOGICALLY INTACT MOUSE BY MYCOBACTERIUM LEPRAE AND APPLICATIONS TO THE EXPERIMENTAL CHEMOTHERAPY OF LEPROSY

5- The First Joint THELEP-Sasakawa Memorial Health Foundation Workshop on Experimental Chemotherapy of Leprosy

J. H. Grosset; Ji Baohong; T. Ito

6- Multiplication of Mycobacterium leprae in normal mice

L. Levy

7- Mouse breeding and husbandry

M. J. Colston; L. Levy

8- Application of the mouse foot-pad technique inimmunologically normal mice in support of clinical drug trials, and a review of earlierclinical drug trials in lepromatous leprosy

L. Levy

9- Drug susceptibility testing of Mycobacterium leprae

Ji Baohong

10- Screening of drugs for activity against Mycobacterium leprae

Ji Baohong; Y. Matsuo; M. J. Colston

11- The normal mouse in experimental chemotherapy

L. Levy

12- Activity of rifampin in infections of normal mice with Mycobacterium leprae

J. H. Grosset; C.C. Guelpa-Lauras

13- Pharmacokinetics in drug screening

J. H. Grosset

THE THYMECTOMIZED-IRRADIATED MOUSE AND THE NEONATALLY THYMECTOMIZED RAT INTHE EXPERIMENTAL CHEMOTHERAPY OF LEPROSY

14- Application of the thymectomized-irradiated mouse to the detection of persisting Mycobacterium leprae

M. J. Colston

15- The THELEP controlled clinical drug trials

Subcommittee on Clinical Trials of the Chemotherapy of Leprosy (THELEP)

16- Detection of persisting Mycobacterium leprae by inoculation of the neonatally thymectomized rat

R. H. Gelber; L. Levy

17- The neonatally thymectomized rat as amodel of the lepromatous patient

R. H. Gelber

THE NUDE MOUSE AND OTHER EXPERIMENTAL ANIMALSIN THE EXPERIMENTAL CHEMOTHERAPY OF LEPROSY

18- The nude mouse-characteristics, breeding and husbandry

R. D. McDermott-Lancaster; T. Ito; K. Kohsaka; M. J. Colston

19- Multiplication of Mycobacterium leprae in the nude mouse, and some applications of nude mice to experimental leprosy

R. D. McDermott-Lancaster; T. Ito; K. Kohsaka; C.-C. Guelpa-Lauras; J. H. Grosset

20- Infection of other experimental animals with Mycobacterium leprae

M. J. Colston; L. Levy

SUMMARY OF THE WORKSHOP

21- Summary of the Workshop

J. H. Grosset; Ji Baohong; T. Ito