%A Vijayalakshmi K
%A Curtis J
%A Gschmeissner S
%A Sibley S
%A Turk JL


%T Effect of presensitization with BCG and <i>Mycobacterium leprae</i> on granuloma  formation to <i>M. leprae</i>

%0 Journal Article

%D 1990

%J International Journal of Leprosy and other Mycobacterial Diseases

%P 0148-916X

%V 58

%N 4

%X Granulomas which develop in draining lymph nodes, following the intradermal injection of cobalt-irradiated <i>Mycobacterium leprae</i> into the ear of the guinea pig 2 and 5 weeks earlier, were studied in animals which had been presensitized with BCG vaccine or <i>M. leprae</i> and compared with granulomas that developed in previously unsensitized guinea pigs. Presensitization with mycobacteria accelerated the development of the granulomas. Granulomas in previously unsensitized guinea pigs were found ultrastructurally to contain phagocytosing macrophages similar to those in lepromatous leprosy, and <i>M. leprae</i> presensitization did not alter the type of granuloma found. Those in BCG-presensitized guinea pigs contained secretory epithelioid cells with rough endoplasmic reticulum similar to those found in borderline tuberculoid leprosy or reversal reactions. The significance of these findings in relation to the current use of vaccines in leprosy is discussed.