%A Cree I %A Smith WCS %A Beck JS %T A quantitative study of the relationship between systemic and histological parameters ot immunity in individual leprosy patients %0 Journal Article %D 1990 %J International Journal of Leprosy and other Mycobacterial Diseases %P 0148-916X %V 58 %N 2 %X A group of 52 untreated leprosy patients were examined to determine the relationship between local and systemic immunological parameters across the clinico-patho-logical spectrum. The Ridley-Jopling classification, bacterial index (131), and granuloma fraction (GF) were assessed in biopsies f rom 40 cases. The densities of apop-toses, mitoses, and plasma cells were also measured. Systemic immunity to mycobacteria was assessed by skin tests with leprosin A and PPD, and by measurement of the serum antibody responses to Mycobacterium leprae, M. tuberculosis, and M. scrofulaceum. The serum responses to phenolic glycolipid-I (PGL-I) of M. leprae was assessed using a glycoconjugate which mimics an immunodominant epitope.
The serum antibody levels and skin test results showed the expected inverse relationship. The BI within lesions showed an inverse correlation with the skin test results, but none of the other histological parameters studied showed a significant relationship with the other measurements of systemic immunity. Our findings suggest that the inverse relationship between delayedtype hypersensitivity and humoral immunity in leprosy patients, which is strong in groups of patients across the leprosy spectrum, is less strong in individual patients than is often thought. The lack of correlation of many histological and systemic parameters suggests that local factors modulate systemic immunity in the pathogenesis of leprosy lesions.